Kitanishi K, Harino S, Suzuki M, Okamoto N, Reinach P
Department of Ophthalmology, Izumiotsu Municipal Hospital, Osaka, Japan.
J Ocul Pharmacol Ther. 2001 Apr;17(2):115-22. doi: 10.1089/10807680151125410.
We investigated the effects of intravenous administration of prostaglandin E1 (PGE1) and lipo-prostaglandin E1 (lipo-PGE1), on optic nerve head blood flow (ONHBF) using ten anesthetized cats. Changes in relative ONHBF were noninvasively and continuously measured with fundus camera-based laser Doppler flowmetry. The blood pressure (BP) decreased significantly by 6 +/- 5 (mean +/- SD)% and 8 +/- 4%, respectively, after PGE1 (30, 100 ng/kg/min) administration, but at either of these concentrations there were no significant changes in ONHBF. On the other hand, with lipo-PGE1 (10 ng/kg/min), the BP remained unchanged, but ONHBF increased significantly by 61 +/- 49%. A larger dose of lipo-PGE1 (30 ng/kg/min) had opposite effects because the BP decreased significantly by 14 +/- 4% after administration, and the ONHBF remained unchanged (i.e., 67 +/- 102%). In all cases, there were no changes in IOP. With 10 ng lipo-PGE1, the large increase in ONHBF can be accounted for by vasodilation since perfusion pressure was unchanged. The inability of 30 ng lipo-PGE1 to affect ONHBF could be ascribed to the decrease in BP resulting in decreased ocular circulation. These results suggest that, in humans, lipo-PGE1 may also increase ONHBF provided that it is used at doses that do not produce large decreases in BP.
我们使用10只麻醉猫，研究了静脉注射前列腺素E1（PGE1）和脂微球前列腺素E1（lipo-PGE1）对视神经乳头血流（ONHBF）的影响。采用基于眼底相机的激光多普勒血流仪，以无创且连续的方式测量相对ONHBF的变化。注射PGE1（30、100 ng/kg/min）后，血压（BP）分别显著下降了6±5（均值±标准差）%和8±4%，但在这两种浓度下，ONHBF均无显著变化。另一方面，注射脂微球前列腺素E1（10 ng/kg/min）时，血压保持不变，但ONHBF显著增加了61±49%。更大剂量的脂微球前列腺素E1（30 ng/kg/min）则产生了相反的效果，因为注射后血压显著下降了14±4%，而ONHBF保持不变（即67±102%）。在所有情况下，眼压（IOP）均无变化。使用10 ng脂微球前列腺素E1时，由于灌注压不变，ONHBF的大幅增加可归因于血管舒张。30 ng脂微球前列腺素E1无法影响ONHBF，可能是由于血压下降导致眼循环减少。这些结果表明，在人类中，只要使用不会导致血压大幅下降的剂量，脂微球前列腺素E1也可能增加ONHBF。
