Kitanishi K, Harino S, Okamoto N, Tani Y, Nishimura K
Department of Ophthalmology, Izumiotsu Municipal Hospital, Osaka-fu, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Mar;101(3):215-9.
We investigated the change of optic nerve head blood flow (ONHBF) and choroidal blood flow (CBF) in response to noradrenaline (NA) intravenously administered in anesthetized cats. NA (0.03, 0.1, 0.3 micrograms/kg/min) was injected 5 minutes continuously via the femoral vein. The relative blood flow and systemic blood pressure were continuously measured before and after NA administration with fundus camera-based laser Doppler flowmetry. Systemic blood pressure increased by 6%, 42% and 48% according to the dose. The changes in ONHBF after NA administration were -1.4 +/- 3.5% (mean +/- standard deviation) with 0.03 micrograms/kg/min, 2.4 +/- 6.9% with 0.1 micrograms/kg/min, -2.2 +/- 4.4% with 0.3 micrograms/kg/min, respectively. It did not change significantly despite doses of NA. CBF did not change significantly with 0.03 micrograms/kg/min. CBF increased significantly by 62.7 +/- 65.4% with 0.1 micrograms/kg/min, and 80.4 +/- 73.1% with 0.3 micrograms/kg/min. These results suggest that ONHBF is autoregulated despite the change of perfusion pressure by NA administration. This response is different from that of CBF.
我们研究了在麻醉猫中静脉注射去甲肾上腺素（NA）后视神经乳头血流（ONHBF）和脉络膜血流（CBF）的变化。通过股静脉连续5分钟注射NA（0.03、0.1、0.3微克/千克/分钟）。在NA给药前后，使用基于眼底相机的激光多普勒血流仪连续测量相对血流和全身血压。全身血压根据剂量分别升高了6%、42%和48%。NA给药后，ONHBF的变化分别为：0.03微克/千克/分钟时为-1.4±3.5%（平均值±标准差），0.1微克/千克/分钟时为2.4±6.9%，0.3微克/千克/分钟时为-2.2±4.4%。尽管使用了不同剂量的NA，ONHBF并未发生显著变化。0.03微克/千克/分钟时CBF无显著变化。0.1微克/千克/分钟时CBF显著增加62.7±65.4%，0.3微克/千克/分钟时增加80.4±73.1%。这些结果表明，尽管NA给药会改变灌注压力，但ONHBF仍受到自身调节。这种反应与CBF的反应不同。
