Wunderlich J L, Cone-Wesson B K
Department of Otolaryngology, University of Melbourne, Victoria, Australia.
J Acoust Soc Am. 2001 Apr;109(4):1526-37. doi: 10.1121/1.1349184.
This study investigated, first, the effect of stimulus frequency on mismatch negativity (MMN), N1, and P2 components of the cortical auditory event-related potential (ERP) evoked during passive listening to an oddball sequence. The hypothesis was that these components would show frequency-related changes, reflected in their latency and magnitude. Second, the effect of stimulus complexity on those same ERPs was investigated using words and consonant-vowel tokens (CVs) discriminated on the basis of formant change. Twelve normally hearing listeners were tested with tone bursts in the speech frequency range (400/440, 1,500/1,650, and 3,000/3,300 Hz), words (/baed/ vs /daed/) and CVs (/bae/ vs /dae/). N1 amplitude and latency decreased as frequency increased. P2 amplitude, but not latency, decreased as frequency increased. Frequency-related changes in MMN were similar to those for N1, resulting in a larger MMN area to low frequency contrasts. N1 amplitude and latency for speech sounds were similar to those found for low tones but MMN had a smaller area. Overall, MMN was present in 46%-71% of tests for tone contrasts but for only 25%-32% of speech contrasts. The magnitude of N1 and MMN for tones appear to be closely related, and both reflect the tonotopicity of the auditory cortex.
本研究首先调查了刺激频率对被动聆听奇偶数序列时诱发的皮质听觉事件相关电位（ERP）的失匹配负波（MMN）、N1和P2成分的影响。假设是这些成分会表现出与频率相关的变化，体现在其潜伏期和波幅上。其次，使用基于共振峰变化区分的单词和辅音 - 元音组合（CV）来研究刺激复杂性对相同ERP的影响。对12名听力正常的受试者进行了测试，刺激包括语音频率范围内的短音突发（400/440、1500/1650和3000/3300赫兹）、单词（/baed/与/daed/）以及CV（/bae/与/dae/）。随着频率增加，N1波幅和潜伏期减小。随着频率增加，P2波幅减小，但潜伏期不变。MMN中与频率相关的变化与N1相似，导致低频对比的MMN面积更大。语音的N1波幅和潜伏期与低音的情况相似，但MMN面积较小。总体而言，MMN出现在46% - 71%的音调对比测试中，但仅出现在25% - 32%的语音对比测试中。音调的N1和MMN波幅似乎密切相关，且两者都反映了听觉皮层的音调定位。
