Isotani T, Tanaka H, Lehmann D, Pascual-Marqui R D, Kochi K, Saito N, Yagyu T, Kinoshita T, Sasada K
The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Lenggstrasse 31, CH-8029, Zurich, Switzerland.
Int J Psychophysiol. 2001 Jun;41(2):143-53. doi: 10.1016/s0167-8760(00)00197-5.
The engagement of different brain regions which implement subjectively experienced emotional states in normals is not completely clarified. Emotional states can conveniently be induced by hypnosis-based suggestions. We studied brain electric activity during hypnotically induced anxiety and relaxation in 11 right-handed normals (5 males, 6 females, mean age 26.5+/-7.6 years). After induction of light hypnosis, anxiety and then relaxation was suggested using a standardized text (reverse sequence in half of the subjects). Nineteen-channel, eyes-closed EEG (20 artifact-free s/subject) was analyzed (source localization using FFT approximation and low resolution electromagnetic tomography, LORETA). Global tests revealed the strongest difference (P<0.005) between EEG source gravity center locations during the two emotional states in the excitatory beta-2 EEG frequency band (18.5-21 Hz). Post hoc tests showed that the sources were located more right during anxiety than during relaxation (P=0.01). LORETA specified that anxiety showed maximally stronger activity than relaxation in right Brodmann area 10, and relaxation showed maximally stronger activity than anxiety in left Brodmann area 22. Clearly, the two induced emotional states were associated with activity of different neural populations. Our results agree with reports on brain activity shifted to the right (especially fronto-temporal) during negative compared with positive emotions, and support the role of beta-2 EEG frequency in emotional states.
在正常人中，实现主观体验到的情绪状态的不同脑区的参与情况尚未完全阐明。情绪状态可以通过基于催眠的暗示方便地诱发。我们研究了11名右利手正常人（5名男性，6名女性，平均年龄26.5±7.6岁）在催眠诱导的焦虑和放松过程中的脑电活动。在诱导轻度催眠后，使用标准化文本暗示焦虑，然后暗示放松（一半受试者采用相反顺序）。分析了19通道闭眼脑电图（每位受试者20个无伪迹样本）（使用快速傅里叶变换近似和低分辨率电磁断层扫描（LORETA）进行源定位）。整体测试显示，在兴奋性β-2脑电频段（18.5 - 21 Hz）的两种情绪状态下，脑电图源重心位置之间存在最强差异（P<0.005）。事后检验表明，焦虑状态下的源位置比放松状态时更靠右（P = 0.01）。LORETA指出，焦虑状态下右侧布罗德曼区10的活动比放松状态时最大程度地更强，而放松状态下左侧布罗德曼区22的活动比焦虑状态时最大程度地更强。显然，两种诱导的情绪状态与不同神经群体的活动相关。我们的结果与关于负面情绪与正面情绪相比大脑活动向右（尤其是额颞叶）转移的报道一致，并支持β-2脑电频率在情绪状态中的作用。
