Wehrhahn C F
Genetics. 1975 Jun;80(2):375-94. doi: 10.1093/genetics/80.2.375.
Most of the models of population genetics are not realistic when applied to data on electrophoretic variants of proteins because the same net charge may result from any of several amino acid combinations. In the absence of realistic models they have, however, been widely used to test competing hypotheses about the origin and maintenance of genetic variation in populations. In this paper I present a general method for determining probability generating functions for electrophoretic state differences. Then I use the method to find allelic state difference distributions for selectively similar electrophoretically detectable alleles in finite natural populations. Predicted patterns of genetic variation, both within and among species, are in reasonable accord with those found in the Drosophila willistoni group by Ayala et al. (1972) and by Ayala and Tracey (1974).
大多数群体遗传学模型在应用于蛋白质电泳变异数据时并不现实，因为相同的净电荷可能由几种氨基酸组合中的任何一种产生。然而，在缺乏现实模型的情况下，它们已被广泛用于检验关于群体中遗传变异的起源和维持的相互竞争的假设。在本文中，我提出了一种确定电泳状态差异的概率生成函数的通用方法。然后我使用该方法来寻找有限自然群体中选择性相似的电泳可检测等位基因的等位基因状态差异分布。预测的物种内和物种间的遗传变异模式与阿亚拉等人（1972年）以及阿亚拉和特雷西（1974年）在威氏果蝇群体中发现的模式合理一致。
