Espinoza E, Carrigan M, Thomas S G, Shaw G, Edison A S
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32610, USA.
Mol Neurobiol. 2000 Feb-Apr;21(1-2):35-56. doi: 10.1385/MN:21:1-2:035.
FMRFamide-like peptide (FLP) amino acid sequences have been collected and statistically analyzed. FLP amino acid composition as a function of position in the peptide is graphically presented for several major phyla. Results of total amino acid composition and frequencies of pairs of FLP amino acids have been computed and compared with corresponding values from the entire GenBank protein sequence database. The data for pairwise distributions of amino acids should help in future structure-function studies of FLPs. To aid in future peptide discovery, a computer program and search protocol was developed to identify FLPs from the GenBank protein database without the use of keywords.
已收集并统计分析了类FMRF酰胺肽（FLP）的氨基酸序列。针对几个主要门类，以图形方式展示了FLP氨基酸组成与其在肽中位置的函数关系。已计算出FLP氨基酸的总组成结果及氨基酸对的频率，并与整个GenBank蛋白质序列数据库中的相应值进行了比较。氨基酸成对分布的数据应有助于未来对FLP的结构-功能研究。为了有助于未来的肽发现，开发了一个计算机程序和搜索协议，以在不使用关键词的情况下从GenBank蛋白质数据库中识别FLP。
