Ravelli A, Caria M C, Buratti S, Malattia C, Temporini F, Martini A
Dipartimento di Scienze Pediatriche, Università di Pavia, Istituto di Ricovero e Cura a Carattere Scientifico S. Matteo, Italy.
J Rheumatol. 2001 Apr;28(4):865-7.
Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.
巨噬细胞活化综合征（MAS）是慢性风湿性疾病，尤其是全身型幼年特发性关节炎（JIA）的一种潜在的危及生命的并发症。多种诱因与MAS的发生有关，包括病毒感染、非甾体抗炎药治疗和金盐注射。我们描述了一名全身型JIA患者，在接受甲氨蝶呤治疗后不久发生了MAS，这表明该药物可被视为JIA患儿发生MAS的潜在诱因。
