载脂蛋白A-I在类固醇诱导的肝细胞DNA和蛋白质合成激活中的作用。
Role of apolipoprotein A-I in steroid-induced activation of DNA and protein synthesis in hepatocytes.
作者信息
Panin L E, Khoshchenko O M, Usynin I F
机构信息
Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2001 Jan;131(1):50-2. doi: 10.1023/a:1017582629775.
PMID:11329082
Abstract
It is demonstrated that anabolic effect of steroid hormones is produced by steroid-apolipoprotein A-I complexes. These complexes accelerate not only protein, but also DNA synthesis and produce both cell hypertrophy and hyperplasia. For realization of their anabolic effect steroid hormones are modified by alpha- and beta-reductases in resident macrophages.
摘要
已证明类固醇激素的合成代谢作用是由类固醇 - 载脂蛋白A - I复合物产生的。这些复合物不仅加速蛋白质合成，还加速DNA合成，并导致细胞肥大和增生。为实现其合成代谢作用，类固醇激素在驻留巨噬细胞中被α - 和β - 还原酶修饰。
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