Masuda H, Kalka C, Asahara T
Department of Medicine (Cardiovascular Research), St. Elizabeth's Medical Center, Tufts University School of Medicine, USA.
Hum Cell. 2000 Dec;13(4):153-60.
Endothelial progenitor cells (EPCs) have been recently isolated from peripheral blood and bone marrow (BM), and shown to be incorporated into sites of physiological and pathological neovascularization in vivo. In contrast to differentiated endothelial cells (ECs), transplantation of EPCs successfully enhanced vascular development by in situ differentiation and proliferation within ischemic organs. Based on such a novel concept of closed up function on EPCs in postnatal neovascularization, the beneficial property of EPC is attractive for cell therapy as well as cell-mediated gene therapy applications targeting regeneration of ischemic tissue.
内皮祖细胞（EPCs）最近已从外周血和骨髓（BM）中分离出来，并被证明可在体内整合到生理性和病理性新生血管形成部位。与分化的内皮细胞（ECs）不同，EPCs的移植通过在缺血器官内原位分化和增殖成功增强了血管发育。基于EPCs在出生后新生血管形成中这种封闭功能的新概念，EPCs的有益特性对于细胞治疗以及针对缺血组织再生的细胞介导基因治疗应用具有吸引力。
