Yoshino A, Honda M, Fukuda M, Araki Y, Hataya H, Sakazume S, Tanaka Y, Kawamura K, Murai T, Kamiyama Y
Department of Pediatrics, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan.
Perit Dial Int. 2001 Mar-Apr;21(2):180-5.
Little is known about the changes in peritoneal equilibration test (PET) values in children on long-term peritoneal dialysis (PD). In the present study, a PET was carried out every 6 months in 39 children (mean age 8.8 +/- 5.5 years) undergoing PD for 6 to 85 months (mean 36.9 +/- 23.1 months). Patients experiencing peritonitis were excluded. Both D/P creatinine (dialysate-to-plasma ratio of creatinine at 4 hours) and D/D0 glucose (ratio of dialysate glucose at 4 hours' dwell time to dialysis glucose at 0 dwell time) were measured 195 times in this series of patients. No remarkable change was found for D/P creatinine or D/D0 glucose during the first 24 months of PD but thereafter, D/P creatinine increased gradually and D/D0 glucose decreased gradually. Mean D/P creatinine increased significantly after the first 24 months of PD: from 0.66 +/- 0.12 during the first 24 months, to 0.70 +/- 0.09 after 25 months and more of PD (p = 0.0051). Mean D/D0 glucose decreased significantly after 24 months of PD: from 0.42 +/- 0.09 during the first 24 months, to 0.38 +/- 0.08 after 25 months and more of PD (p = 0.0015). The most significant change for both D/P creatinine and D/D0 glucose occurred after 24 months of PD. It seems reasonable to consider the mean PET values at 24 months of PD as the standard PET values.
关于长期腹膜透析（PD）患儿腹膜平衡试验（PET）值的变化，人们了解甚少。在本研究中，对39例接受PD治疗6至85个月（平均36.9±23.1个月）的患儿（平均年龄8.8±5.5岁）每6个月进行一次PET检查。排除发生腹膜炎的患者。在这组患者中，共测量了195次D/P肌酐（4小时时透析液与血浆肌酐之比）和D/D0葡萄糖（4小时驻留时间的透析液葡萄糖与0驻留时间的透析液葡萄糖之比）。在PD治疗的前24个月，D/P肌酐或D/D0葡萄糖未发现明显变化，但此后，D/P肌酐逐渐升高，D/D0葡萄糖逐渐降低。PD治疗24个月后，平均D/P肌酐显著升高：从最初24个月的0.66±0.12，升至25个月及更长时间PD治疗后的0.70±0.09（p = 0.0051）。PD治疗24个月后，平均D/D0葡萄糖显著降低：从最初24个月的0.42±0.09，降至25个月及更长时间PD治疗后的0.38±0.08（p = 0.0015）。D/P肌酐和D/D0葡萄糖的最显著变化均发生在PD治疗24个月后。将PD治疗24个月时的平均PET值视为标准PET值似乎是合理的。
