Suter C, Müller-Doblies U U, Hatt J M, Deplazes P
Institute of Parasitology, University of Zurich, Switzerland.
Vet Rec. 2001 Apr 14;148(15):478-80. doi: 10.1136/vr.148.15.478.
The efficacy of fenbendazole for preventing an experimental infection of Encephalitozoon cuniculi and for eliminating the spores from the central nervous system of naturally infected rabbits was investigated. Fenbendazole (20 mg/kg bodyweight daily) was administered from seven days before until two or 21 days after rabbits had been infected orally with 10(6) spores of E. cuniculi. Both regimens were effective in preventing the establishment of the parasites, as demonstrated by negative parasitic-specific serology and by the failure to isolate the parasite from brain tissue. In naturally infected, seropositive rabbits, parasites were successfully isolated from seven of nine untreated animals, but not from the brain tissue of eight animals treated with fenbendazole-medicated pellets for four weeks.
研究了芬苯达唑预防兔脑原虫实验性感染以及从自然感染兔的中枢神经系统清除孢子的效果。在兔经口感染10(6)个兔脑原虫孢子前7天至感染后2天或21天，每日给予芬苯达唑（20mg/kg体重）。两种给药方案均能有效预防寄生虫的定植，这通过寄生虫特异性血清学阴性以及未能从脑组织中分离出寄生虫得以证明。在自然感染的血清阳性兔中，9只未治疗动物中有7只成功分离出寄生虫，但在用芬苯达唑药饵治疗4周的8只动物的脑组织中未分离出寄生虫。
