Wucherpfennig K W
Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
J Autoimmun. 2001 May;16(3):293-302. doi: 10.1006/jaut.2000.0499.
Infectious agents are thought to play an important role in the development of autoimmune diseases. Sequence similarity between infectious agents and self-proteins (molecular mimicry) has been proposed as a mechanism for the induction of autoimmunity [1]. However, it has been difficult to identify microbial peptides that activate autoreactive T cells using conventional sequence alignments. This chapter reviews progress made in the identification of such microbial peptides based on the analysis of structural features that are important for TCR recognition of MHC-bound peptides [2].
感染因子被认为在自身免疫性疾病的发展中起重要作用。感染因子与自身蛋白之间的序列相似性（分子模拟）已被提出作为诱导自身免疫的一种机制[1]。然而，使用传统的序列比对来鉴定激活自身反应性T细胞的微生物肽一直很困难。本章综述了基于对MHC结合肽的TCR识别重要的结构特征分析，在鉴定此类微生物肽方面取得的进展[2]。
