克氏锥虫的抗体依赖性细胞毒性：来自正常人血液的效应细胞的特征
Antibody-dependent cellular cytotoxicity of Trypanosoma cruzi: characterization of the effector cell from normal human blood.
作者信息
Madeira E D, de Andrade A F, Bunn-Moreno M M, Barcinski M
出版信息
Infect Immun. 1979 Jul;25(1):34-8. doi: 10.1128/iai.25.1.34-38.1979.
Abstract
The antibody-dependent cellular cytotoxicity activity of normal human blood cells against epimastigotes of Trypanosoma cruzi was measured by the release of incorporated [3H]uridine. Sera from patients with chronic Chagas' disease were used to sensitize the parasites to the lytic activity of the effector cells. Different steps of peripheral blood cell purification were employed, and different cell subpopulations were tested as effectors in the system. The main cytotoxic activity was detected in the granulocyte-rich fraction.
摘要
通过掺入的[3H]尿苷的释放来测定正常人血细胞对克氏锥虫无鞭毛体的抗体依赖性细胞毒性活性。使用慢性恰加斯病患者的血清使寄生虫对效应细胞的裂解活性敏感。采用外周血细胞纯化的不同步骤，并测试不同的细胞亚群作为该系统中的效应细胞。主要的细胞毒性活性在富含粒细胞的部分中检测到。
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