一种从冬绿树树皮中提取的具有抗伤害感受活性的倍半萜杜松烷。
A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark.
作者信息
Malheiros A, Filho V C, Schmitt C B, Scheidt C, Calixto J B, Monache F D, Yunes R A
机构信息
Departamento de Farmacologia, Trindade, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
出版信息
Phytochemistry. 2001 May;57(1):103-7. doi: 10.1016/s0031-9422(00)00515-x.
Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
除了三种已知的菖蒲烷型倍半萜——多香树醛、1-β-(对甲氧基肉桂酰基)多香树醛和木卡醛外，从智利冬绿树（林仙科）树皮中分离出了一种名为地衣烷型倍半萜的倍半萜菖蒲烷。其结构是根据光谱证据阐明的。地衣烷型倍半萜对醋酸诱导的疼痛表现出抗伤害感受作用，活性比多香树醛低约3倍。
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