白水阿罗约病毒：塔卡里比血清复合群病毒（沙粒病毒科）之间基因重组的自然证据

The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae).

作者信息

Charrel R N, de Lamballerie X, Fulhorst C F

机构信息

Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.

出版信息

Virology. 2001 May 10;283(2):161-6. doi: 10.1006/viro.2001.0874.

DOI:10.1006/viro.2001.0874

PMID:11336541

Abstract

The Tacaribe serocomplex (family Arenaviridae) comprises three phylogenetic lineages, designated A, B, and C. The sequence of a 3278-nt fragment of the small genomic segment of the Whitewater Arroyo (WWA) virus was determined to extend our knowledge on the phylogenetic relationship of this newly discovered North American Tacaribe complex virus to other arenaviruses. Independent analyses of full-length nucleoprotein (N) and glycoprotein precursor (GPC) amino acid sequences indicated that the WWA virus N and GPC genes are descended from a lineage A virus and lineage B virus, respectively. The different phylogenetic histories of the N and GPC genes indicate that the WWA virus genome is a product of recombination between two Tacaribe complex viruses.

摘要

塔卡里贝血清复合体（沙粒病毒科）由三个系统发育谱系组成，分别命名为A、B和C。测定了白水阿罗约（WWA）病毒小基因组片段的3278个核苷酸的序列，以扩展我们对这种新发现的北美塔卡里贝复合体病毒与其他沙粒病毒之间系统发育关系的认识。对全长核蛋白（N）和糖蛋白前体（GPC）氨基酸序列的独立分析表明，WWA病毒的N基因和GPC基因分别源自A谱系病毒和B谱系病毒。N基因和GPC基因不同的系统发育历史表明，WWA病毒基因组是两种塔卡里贝复合体病毒之间重组的产物。