Ehrenpreis E D, Rubin D T, Ginsburg P M, Meyers J S
Department of Gastroenterology, University of Chicago Hospitals, 5841 South Maryland Avenue, MC 4076, Chicago, Illinois 60637, USA.
Expert Opin Pharmacother. 2001 Jan;2(1):41-5. doi: 10.1517/14656566.2.1.41.
Anal fissure is a painful condition that is caused by anodermal tearing after the passage of hard stool. Severe cases result in involuntary internal anal sphincter spasm and have traditionally been treated surgically with a lateral sphincterotomy. Investigators have demonstrated that nitric oxide causes relaxation of the smooth muscle of the anal canal, so topical nitroglycerin ointment preparations have recently been studied as an efficacious alternative to surgery. Despite the fact that there are a number of trials examining topical nitroglycerin for the treatment of anal fissures, there remains no consensus about concentrations, compositions and applications necessary to obtain good results. This review summarises current literature regarding topical nitroglycerin pharmacotherapy for anal fissure.
肛裂是一种因硬便通过后导致肛管皮肤撕裂而引起的疼痛病症。严重病例会导致肛门内括约肌不由自主地痉挛，传统上通过外侧括约肌切开术进行手术治疗。研究人员已证明一氧化氮可使肛管平滑肌松弛，因此局部使用硝酸甘油软膏制剂最近已作为一种有效的手术替代方法进行研究。尽管有多项试验研究局部使用硝酸甘油治疗肛裂，但对于获得良好疗效所需的浓度、成分和应用方法仍未达成共识。本综述总结了有关局部使用硝酸甘油药物治疗肛裂的当前文献。
