Liepert J, Haueisen J, Hegemann S, Weiller C
Department of Neurology, Friedrich Schiller University of Jena, Jena, Germany.
Clin Neurophysiol. 2001 May;112(5):917-22. doi: 10.1016/s1388-2457(01)00521-1.
To test electrophysiologically, if patients with mitochondriopathy but without evidence of myocloni have subclinical signs of disinhibition in motor and somatosensory cortices.
Two patients were studied and compared with age-matched control groups.
In both patients, giant somatosensory evoked potentials after median nerve stimulation and a reduced intracortical inhibition tested by transcranial magnetic stimulation in a paired pulse paradigm indicated a dysfunction of inhibitory circuits in the motor as well as the somatosensory cortex. In addition, the somatosensory evoked 600 Hz activity recorded by magnetoencephalography was abolished.
Patients with mitochondriopathy may suffer from a subclinical disturbance of inhibition in the sensorimotor cortex. The loss of 600 Hz activity indicates that these high-frequency oscillations could reflect the activity of inhibitory neurons in the somatosensory cortex.
通过电生理学测试，线粒体病患者若没有肌阵挛证据，其运动和体感皮层是否存在抑制解除的亚临床体征。
对两名患者进行研究，并与年龄匹配的对照组进行比较。
在两名患者中，正中神经刺激后的巨大体感诱发电位以及经颅磁刺激在配对脉冲模式下测试的皮质内抑制减弱，表明运动和体感皮层的抑制性回路功能障碍。此外，脑磁图记录的体感诱发600Hz活动消失。
线粒体病患者可能存在感觉运动皮层抑制的亚临床紊乱。600Hz活动的丧失表明这些高频振荡可能反映体感皮层抑制性神经元的活动。
