Weinstein-Oppenheimer C R, Blalock W L, Steelman L S, Chang F, McCubrey J A
Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Brody Building of Medical Sciences 5N98C, Greenville, NC 27858, USA.
Pharmacol Ther. 2000 Dec;88(3):229-79. doi: 10.1016/s0163-7258(00)00085-1.
This review focuses on the Ras-Raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signal transduction pathway and the consequences of its unregulation in the development of cancer. The roles of some of the cell membrane receptors involved in the activation of this pathway, the G-protein Ras, the Raf, MEK and ERK kinases, the phosphatases that regulate these kinases, as well as the downstream transcription factors that become activated, are discussed. The roles of the Ras-Raf-MEK-ERK pathway in the regulation of apoptosis and cell cycle progression are also analyzed. In addition, potential targets for pharmacological intervention in growth factor-responsive cells are evaluated.
本综述聚焦于Ras-Raf-丝裂原活化蛋白激酶激酶（MEK）-细胞外信号调节激酶（ERK）信号转导通路及其失调在癌症发展中的后果。讨论了参与该通路激活的一些细胞膜受体、G蛋白Ras、Raf、MEK和ERK激酶、调节这些激酶的磷酸酶以及被激活的下游转录因子的作用。还分析了Ras-Raf-MEK-ERK通路在细胞凋亡和细胞周期进程调节中的作用。此外，评估了生长因子反应性细胞中药物干预的潜在靶点。
