小鼠促肾上腺皮质激素释放激素缺乏的生理学

The physiology of corticotropin-releasing hormone deficiency in mice.

作者信息

Muglia L J, Jacobson L, Weninger S C, Karalis K P, Jeong K, Majzoub J A

机构信息

Departments of Pediatrics, Molecular Biology and Pharmacology, and Obstetrics and Gynecology, Washington University School of Medicine, and St. Louis Children's Hospital, St. Louis, MO 63110, USA.

出版信息

Peptides. 2001 May;22(5):725-31. doi: 10.1016/s0196-9781(01)00385-0.

DOI:10.1016/s0196-9781(01)00385-0

PMID:11337085

Abstract

A review of the generation and characterization of corticotropin-releasing hormone (CRH)-deficient mice is presented. The studies summarized demonstrate the central role of CRH in the pituitary-adrenal axis response to stress, circadian stimulation, and glucocorticoid withdrawal. Additionally, pro-inflammatory actions of CRH at sites of local inflammation are given further support. In contrast, behavioral effects during stress that had been ascribed to CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress in CRH-deficient mice strongly suggests the importance of other, possibly as yet undiscovered, CRH-like molecules.

摘要

本文综述了促肾上腺皮质激素释放激素（CRH）缺陷小鼠的生成及特性。总结的研究表明，CRH在垂体-肾上腺轴对应激、昼夜节律刺激和糖皮质激素撤药的反应中起核心作用。此外，CRH在局部炎症部位的促炎作用得到了进一步支持。相比之下，CRH缺陷小鼠在应激期间归因于CRH作用的行为效应并未改变。CRH缺陷小鼠对应激的正常行为反应强烈表明其他可能尚未发现的CRH样分子的重要性。