Gravanis A, Makrigiannakis A, Zoumakis E, Margioris A N
Department of Pharmacology, Medical School, University of Crete, 71110, Heraklion, Greece.
Peptides. 2001 May;22(5):785-93. doi: 10.1016/s0196-9781(01)00392-8.
In human endometrium, both epithelial and stroma cells produce corticotropin-releasing hormone (CRH). Both types of cells also possess specific CRH-binding sites indicating a local effect of endometrial CRH. The transcription of the CRH gene in human endometrium is under the control of steroid hormones and locally produced prostanoids and interleukins. Endometrial CRH interacts with locally produced prostaglandins and interleukins. Based on these observations it can be hypothesized that CRH, prostaglandins and interleukins form a network responsible for the communication between epithelial and stromal cells, at the level of the endometrium, and between endometrial and myometrial cells at the level of uterus. The net product of these interaction is the micro-regulation of the decidualizing process and the preparation of endometrium for the implantation/nidation of the conceptus. Indeed, this network may represent the core of the intrauterine neuroendocrine-immune interactions involved in the decidualization of stroma and implantation of blastocyst. In addition, this network appears to be essential for the fine-tuning of myometrial tone.
在人类子宫内膜中，上皮细胞和基质细胞均能产生促肾上腺皮质激素释放激素（CRH）。这两种细胞类型也都拥有特定的CRH结合位点，表明子宫内膜CRH具有局部作用。人类子宫内膜中CRH基因的转录受甾体激素以及局部产生的前列腺素和白细胞介素的调控。子宫内膜CRH与局部产生的前列腺素和白细胞介素相互作用。基于这些观察结果，可以推测CRH、前列腺素和白细胞介素形成了一个网络，负责在子宫内膜水平上上皮细胞与基质细胞之间以及子宫水平上子宫内膜细胞与肌层细胞之间的通讯。这些相互作用的最终产物是对蜕膜化过程的微观调节以及为孕体着床/植入准备子宫内膜。实际上，这个网络可能代表了参与基质蜕膜化和胚泡植入的子宫内神经内分泌-免疫相互作用的核心。此外，这个网络似乎对于微调肌层张力至关重要。
