Perumal D
Department of Pharmacy, University of Durban-Westville, Private Bag X54001, 4000, Kwazulu-Natal, Durban, South Africa.
Int J Pharm. 2001 May 7;218(1-2):1-11. doi: 10.1016/s0378-5173(00)00686-4.
The emulsion solvent diffusion was employed to prepare modified release microspheres of ibuprofen. The technique was optimised for the following processing variables: the absence/presence of baffles in the reaction vessel, agitation rate and drying time. Thereafter, the influence of various formulation factors on the microencapsulation efficiency, in vitro drug release and micromeritic properties was examined. The variables included the methacrylic polymer, Eudragit(R) RS 100, ibuprofen content and the volume of ethanol used during microencapsulation. The results obtained were then interpreted on a triangular phase diagram to map the region of microencapsulation, as well as those formulations that yielded suitable modified release ibuprofen microspheres.
采用乳液溶剂扩散法制备布洛芬缓释微球。针对以下工艺变量对该技术进行了优化：反应容器中是否有挡板、搅拌速率和干燥时间。此后，研究了各种制剂因素对微囊化效率、体外药物释放和粉体学性质的影响。变量包括甲基丙烯酸聚合物Eudragit® RS 100、布洛芬含量以及微囊化过程中使用的乙醇体积。然后在三角相图上解释所得结果，以绘制微囊化区域以及产生合适的布洛芬缓释微球的制剂区域。
