Gibaldi M, Grundhofer B
J Pharm Sci. 1975 Jun;64(6):1064-6. doi: 10.1002/jps.2600640649.
A comparison of the bioavailability of salicylate from five brands of commercially available aspirin rectal suppositories in an adult panel is presented. All brands show slow absorption compared to oral administration of the drug in tablet form. At best, about 40% of the dose (on the average) was absorbed when retention time in the bowel was limited to 2 hr. However, four out of the five brands give substantially lower absorption rates so that only about 20% of the aspirin is available.
本文介绍了在一个成人组中对五种市售阿司匹林直肠栓剂中水杨酸盐生物利用度的比较。与口服片剂形式的药物相比，所有品牌的栓剂吸收都较慢。在肠道停留时间限制为2小时的情况下，最多约40%的剂量（平均）被吸收。然而，五个品牌中的四个吸收速率要低得多，以至于只有约20%的阿司匹林能够被吸收利用。
