Stozek T
Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):227-33.
The rate of release of acetylsalicylic acid (ASA) coated and uncoated from suppositories in vitro, and the bioavailability of ASA in vivo were examined. The coating reduces the rate of release of activite drug from suppositories. In vivo the coating delays the obtention of the maximum concentration of salicylates in urine, but doesn't have any essential effect on cummulative amount of salicylates in urine.
研究了乙酰水杨酸（ASA）包衣和未包衣栓剂在体外的释放速率以及ASA在体内的生物利用度。包衣降低了活性药物从栓剂中的释放速率。在体内，包衣延迟了尿中水杨酸盐最大浓度的获得，但对尿中水杨酸盐的累积量没有任何实质性影响。
