Bottari F, Colo G D, Nannipieri E, Saettone M F, Serafini M F
J Pharm Sci. 1975 Jun;64(6):946-9. doi: 10.1002/jps.2600640610.
The applicability of a permeation rate technique to the determination of drug-macromolecule interactions was tested by measuring the extent of interaction of methylparaben with polyvinylpyrrolidone and polysorbate 80. Results were in agreement with literature data obtained by other techniques. The present method, although restricted to permeant molecules that diffuse readily through nonporous nylon membranes, is of potential value for investigations of drug binding by macromolecules not retained by porous dialysis membranes.
通过测量对羟基苯甲酸甲酯与聚乙烯吡咯烷酮和聚山梨酯80的相互作用程度，测试了渗透速率技术在测定药物-大分子相互作用方面的适用性。结果与通过其他技术获得的文献数据一致。本方法虽然仅限于能容易地透过无孔尼龙膜的渗透分子，但对于研究未被多孔透析膜截留的大分子与药物的结合具有潜在价值。
