Khalafallah N, Gouda M W, Khalil S A
J Pharm Sci. 1975 Jun;64(6):991-4. doi: 10.1002/jps.2600640621.
To explore the effect of dioctyl sodium sulfosuccinate on drug absorption in humans, the urinary excretion of a poorly absorbable drug, phenolsulfonphthalein, administered in solution with and without the surfactant was determined. Coadministration of a therapeutic dose of the surfactant with the drug solution resulted in a significant increase in the initial rate of absorption. A small increase in the extent of absorption was also observed. Pretreatment with the surfactant for 6 nights, followed by administration of the drug on the 7th day, did not significantly change the rate of extent of absorption. The surfactant is thought to have a direct effect on the GI membrane, resulting in a temporary change in its permeability. This effect appears to be reversible after a few hours.
为探究磺基琥珀酸二辛酯钠对人体药物吸收的影响，测定了难吸收药物酚磺酞在添加和未添加该表面活性剂的溶液中的尿排泄情况。将治疗剂量的表面活性剂与药物溶液共同给药，导致吸收初始速率显著增加。吸收程度也有小幅增加。用表面活性剂预处理6个晚上，然后在第7天给药，吸收速率和程度没有显著变化。该表面活性剂被认为对胃肠道膜有直接作用，导致其通透性暂时改变。这种作用在几小时后似乎是可逆的。
