Gouda M W, Khalafalah N, Khalil S A
J Pharm Sci. 1977 May;66(5):727-8. doi: 10.1002/jps.2600660531.
The effect of administration of 600-and 300-mg doses of sodium deoxycholate 1 hr before phenolsulfonphthalein solution is reported. The 600-mg dose caused a decrease in drug bioavailability as measured by the total amount excreted in 24 hr. The 300-mg dose cause and increase in the initial phenolsulfonphthalein absorption rate, suggesting a direct action of the bile salt on membrane permeability. The decrease in absorption upon administration of 600 mg was attributed to micellar entrapment of the drug molecule.
据报道，在注射酚磺酞溶液前1小时给予600毫克和300毫克剂量的脱氧胆酸钠的效果。600毫克剂量导致药物生物利用度降低，这通过24小时内排泄的总量来衡量。300毫克剂量导致酚磺酞初始吸收速率增加，表明胆盐对膜通透性有直接作用。给予600毫克后吸收减少归因于药物分子被胶束截留。
