Teshome T, Seyoum B
Department of Ophthalmology, Faculty of Medicine, Addis Ababa University, Addis Ababa.
Ethiop Med J. 2001 Jan;39(1):1-8.
In a prospective study, we evaluated the clinical manifestations, severity, complication and management of Graves' thyroid ophthalmopathy (GTO) in 37 Ethiopian patients. Twenty-seven were females and 10 were males (F:M = 2.7:1). The mean age was 35 years (range 19-70 yrs). The mean duration of ocular symptoms was 33.4 months (range 2-120 months) while the mean duration of hyperthyroid symptoms was 36.2 months (range 6-120 months). GTO was found in 30 (81.1%) hyperthyroid, 1 (2.7%) hypothyroid and 5 (13.5%) euthyroid patients. Upper lid retraction was the most common clinical finding, being detected in 31 (83.8%) of the patients. One (2.7%) patient had marked extraocular muscle involvement, involving the inferior rectus muscle of one eye. Though 18 (48.6) patients had signs of soft tissue inflammation, only 4 (10.8%) required the administration of systemic steroids to control the inflammatory process. None of our patients had sight loss from the complications of GTO. Larger prospective studies are suggested to evaluate both the prevalence and possible racial difference in its clinical presentation.
在一项前瞻性研究中，我们评估了37例埃塞俄比亚格雷夫斯甲状腺眼病（GTO）患者的临床表现、严重程度、并发症及治疗情况。其中女性27例，男性10例（女∶男 = 2.7∶1）。平均年龄为35岁（范围19 - 70岁）。眼部症状的平均持续时间为33.4个月（范围2 - 120个月），而甲状腺功能亢进症状的平均持续时间为36.2个月（范围6 - 120个月）。在30例（81.1%）甲状腺功能亢进、1例（2.7%）甲状腺功能减退和5例（13.5%）甲状腺功能正常的患者中发现了GTO。上睑退缩是最常见的临床表现，31例（83.8%）患者出现此症状。1例（2.7%）患者有明显的眼外肌受累，累及一只眼睛的下直肌。虽然18例（48.6%）患者有软组织炎症体征，但只有4例（10.8%）需要使用全身类固醇来控制炎症过程。我们的患者均未因GTO并发症而失明。建议开展更大规模的前瞻性研究，以评估其患病率及临床表现中可能存在的种族差异。
