Schneider E G, Goldsmith R S, Arnaud C D, Knox F G
Kidney Int. 1975 May;7(5):317-24. doi: 10.1038/ki.1975.44.
Role of parathyroid hormone in the phosphaturia of extracellular fluid volume expansion. Acute expansion of the extracellular fluid volume increases the urinary excretion of phosphate. The present study examined the importance of increased plasma parathyroid hormone concentration in the phosphaturia accompanying acute extracellular fluid volume expansion (ECVE). Infusion of a calcium-free Ringer's solution into dogs was associated with increased urinary phosphateexcretion and serum immunoreactive parathyroid hormone concentration (iPTH), the latter being significantly correlated with a decrease in plasma ionized calcium concentration. Prevention of the fall in plasma ionized calcium concentration by infusion of a calcium containing Ringer's solution prevented the increase in serum iPTH but the magnitude of the phosphaturia was not affected.
甲状旁腺激素在细胞外液量扩张性磷尿中的作用。细胞外液量的急性扩张会增加磷酸盐的尿排泄。本研究探讨了血浆甲状旁腺激素浓度升高在急性细胞外液量扩张（ECVE）伴随的磷尿中的重要性。向犬输注无钙林格氏液会导致尿磷酸盐排泄增加以及血清免疫反应性甲状旁腺激素浓度（iPTH）升高，后者与血浆离子钙浓度降低显著相关。通过输注含钙林格氏液防止血浆离子钙浓度下降可防止血清iPTH升高，但磷尿的程度不受影响。
