Titlestad K, Georgsen J, Jorgensen J, Kristensen T
Department of Clinical Immunology, Odense University Hospital, DK-5000 Odense C, Denmark.
Vox Sang. 2001 Jan;80(1):40-7. doi: 10.1046/j.1423-0410.2001.00001.x.
Considering the clinical importance of blood transfusions, the limited knowledge of transfusion practices is remarkable. New methods are needed to elucidate the observed variation of transfusion practices.
All patients transfused or pretransfusion tested (i.e. at risk for blood transfusion) at two tertiary teaching hospitals during the full years of 1997 and 1998 were included in the study.
The observed practices contained substantial variance at the level of hospitals. The contributions to the total variance of the different specialities were highly significant, as was the contribution of hospitals to the variance in plasma and platelet transfusions. Significant interactions between hospitals and specialities were observed in transfusion of red cells, plasma and platelets.
To our knowledge this is the first survey of this size to combine transfusions, diagnoses and biochemical tests, exclusively based on an existing computerized register. The aim is to establish a basis for comparison of local transfusion practices with other commensurate hospitals and regions at a national (and international) level.
鉴于输血在临床上的重要性,人们对输血实践的了解却极为有限,这一点颇为引人注目。需要新的方法来阐释观察到的输血实践差异。
本研究纳入了1997年全年及1998年全年在两家三级教学医院接受输血或输血前检测(即有输血风险)的所有患者。
在医院层面观察到的实践存在显著差异。不同专科对总差异的贡献极为显著,医院对血浆和血小板输血差异的贡献同样如此。在红细胞、血浆和血小板输血方面观察到医院与专科之间存在显著交互作用。
据我们所知,这是首次基于现有的计算机化登记系统,将输血、诊断和生化检测相结合的大规模调查。目的是为在国家(及国际)层面将当地输血实践与其他类似医院和地区进行比较奠定基础。