Norgaard Astrid, De Lichtenberg Trine Honnens, Nielsen Jens, Johansson Pär I
Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
JN Statistical Consulting, Copenhagen, Denmark.
Blood Transfus. 2014 Oct;12(4):509-19. doi: 10.2450/2014.0282-13. Epub 2014 Jun 5.
The practice of transfusing red blood cells is still liberal in some centres suggesting a lack of compliance with guidelines recommending transfusion of red blood cells at haemoglobin levels of 6-8 g/dL in the non-bleeding patient. Few databases provide ongoing feedback of data on pre-transfusion haemoglobin levels at the departmental level. In a tertiary care hospital, no such data were produced before this study. Our aim was to establish a Patient Blood Management database based on electronic data capture in order to monitor compliance with transfusion guidelines at departmental and hospital levels.
Hospital data on admissions, diagnoses and surgical procedures were used to define the populations of patients. Data on haemoglobin measurements and red blood cell transfusions were used to calculate pre-transfusion haemoglobin, percentage of transfused patients and transfusion volumes.
The model dataset include 33,587 admissions, of which 10% had received at least one unit of red blood cells. Haemoglobin measurements preceded 96.7% of the units transfused. The median pre-transfusion haemoglobin was 8.9 g/dL (interquartile range 8.2-9.7) at the hospital level. In only 6.5% of the cases, transfusion was initiated at 7.3 g/dL or lower as recommended by the Danish national transfusion guideline. In 27% of the cases, transfusion was initiated when the haemoglobin level was 9.3 g/dL or higher, which is not recommended. A median of two units was transfused per transfusion episode and per hospital admission. Transfusion practice was more liberal in surgical and intensive care units than in medical departments.
We described pre-transfusion haemoglobin levels, transfusion rates and volumes at hospital and departmental levels, and in surgical subpopulations. Initial data revealed an extensive liberal practice and low compliance with national transfusion guidelines, and identified wards in need of intervention.
在一些医疗中心,红细胞输注的做法仍然较为随意,这表明在遵循指南方面存在不足。指南建议,对于非出血患者,血红蛋白水平在6 - 8 g/dL时才进行红细胞输注。很少有数据库能在科室层面提供关于输血前血红蛋白水平数据的持续反馈。在一家三级护理医院,在本研究之前尚未生成此类数据。我们的目标是建立一个基于电子数据采集的患者血液管理数据库,以监测科室和医院层面遵循输血指南的情况。
利用医院关于入院、诊断和外科手术的数据来界定患者群体。血红蛋白测量数据和红细胞输注数据用于计算输血前血红蛋白、输血患者百分比和输血量。
模型数据集包括33587例入院病例,其中10%的患者接受了至少1个单位的红细胞输注。96.7%的输注单位之前进行了血红蛋白测量。在医院层面,输血前血红蛋白的中位数为8.9 g/dL(四分位间距8.2 - 9.7)。仅6.5%的病例按照丹麦国家输血指南的建议,在血红蛋白水平为7.3 g/dL或更低时开始输血。在27%的病例中,当血红蛋白水平为9.3 g/dL或更高时开始输血,这是不推荐的做法。每次输血事件和每次住院的输血中位数为2个单位。外科和重症监护病房的输血做法比内科更随意。
我们描述了医院和科室层面以及外科亚组中的输血前血红蛋白水平、输血率和输血量。初步数据显示存在广泛的随意做法且对国家输血指南的遵循度较低,并确定了需要干预的病房。