Gottesman M E, Quadro L, Blaner W S
Institute of Cancer Research and Department of Medicine, Columbia University, College of Physicians and Surgeons, New York 10032, USA.
Bioessays. 2001 May;23(5):409-19. doi: 10.1002/bies.1059.
Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago.1)
在过去几年中，小鼠遗传学的发现对我们理解维生素A代谢产生了直接影响。尽管小鼠体内维生素A的代谢确实有一些特殊特征（例如肝脏和肺部视黄酯的大量储存），但构建基因敲除和转基因小鼠模型的能力已经产生了大量与理解维生素A运输、储存和降解的一般原则直接相关的信息。我们将在下面讨论通过一些基因工程小鼠品系所观察到的维生素A代谢情况，这些品系中影响维生素A代谢的基因发生了改变。这些品系中最早的是在仅仅八年前才首次报道，这一事实证明了这种实验方法的新颖性。
