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蛋白酶抑制剂治疗后出现全葡萄膜炎的免疫恢复性视网膜炎。

Immune recovery vitritis presenting as panuveitis following therapy with protease inhibitors.

作者信息

Biswas J, Choudhry S, Solomon S

机构信息

Medical Research Foundation, Chennai, India.

出版信息

Indian J Ophthalmol. 2000 Dec;48(4):313-5.

PMID:11340892
Abstract

Immune reconstitution in acquired immunodeficiency syndrome (AIDS) patients on highly active anti-retroviral therapy (HAART) with cytomegalovirus (CMV) retinitis manifested as posterior segment intraocular inflammation has been reported. We report an adult HIV-positive Indian male with clinically inactive CMV retinitis who developed panuveitis with hypopyon. This was related to immune recovery mediated by combination anti-retroviral treatment, including protease inhibitors.

摘要

据报道，接受高效抗逆转录病毒疗法（HAART）治疗的获得性免疫缺陷综合征（AIDS）患者，若患有表现为眼后段眼内炎症的巨细胞病毒（CMV）视网膜炎，会出现免疫重建。我们报告了一名成年HIV阳性的印度男性，其患有临床静止性CMV视网膜炎，却发展为伴有前房积脓的全葡萄膜炎。这与包括蛋白酶抑制剂在内的联合抗逆转录病毒治疗介导的免疫恢复有关。

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Immune recovery vitritis presenting as panuveitis following therapy with protease inhibitors.蛋白酶抑制剂治疗后出现全葡萄膜炎的免疫恢复性视网膜炎。
Indian J Ophthalmol. 2000 Dec;48(4):313-5.
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引用本文的文献

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J Ophthalmic Inflamm Infect. 2014 Dec;4(1):21. doi: 10.1186/s12348-014-0021-0. Epub 2014 Aug 29.
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Cytomegalovirus Uveitis with Hypopyon Mimicking Bacterial Endophthalmitis.巨细胞病毒性葡萄膜炎伴前房积脓，酷似细菌性眼内炎。
Case Rep Ophthalmol Med. 2015;2015:489813. doi: 10.1155/2015/489813. Epub 2015 May 11.
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Immune recovery uveitis: pathogenesis, clinical symptoms, and treatment.
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Mediators Inflamm. 2014;2014:971417. doi: 10.1155/2014/971417. Epub 2014 Jun 24.
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Frosted branch angiitis as a result of immune recovery uveitis in a patient with cytomegalovirus retinitis.巨细胞病毒性视网膜炎患者免疫恢复性葡萄膜炎导致的霜枝样视网膜血管炎
J Ophthalmic Inflamm Infect. 2013 Jun 22;3(1):52. doi: 10.1186/1869-5760-3-52.
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[Immune reconstitution syndrome].[免疫重建综合征]
Z Rheumatol. 2012 Apr;71(3):187-98. doi: 10.1007/s00393-011-0858-7.
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Impact of highly active antiretroviral therapy on ophthalmic manifestations in human immunodeficiency virus / acquired immune deficiency syndrome.高效抗逆转录病毒疗法对人类免疫缺陷病毒/获得性免疫缺陷综合征眼部表现的影响。
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