Urban Beata, Bakunowicz-Łazarczyk Alina, Michalczuk Marta
Department of Pediatric Ophthalmology and Strabismus, Medical University of Białystok, Białystok University Children's Hospital, Waszyngtona Street 17, 15-274 Białystok, Poland.
Department of Pediatric Ophthalmology and Strabismus, Białystok University Children's Hospital, Waszyngtona Street 17, 15-274 Białystok, Poland.
Mediators Inflamm. 2014;2014:971417. doi: 10.1155/2014/971417. Epub 2014 Jun 24.
IRU is the most common form of immune reconstitution inflammatory syndrome in HIV-infected patients with cytomegalovirus retinitis who are receiving highly active antiretroviral therapy (HAART). Among patients with CMV in the HAART era, immune recovery may be associated with a greater number of inflammatory complications, including macular edema and epiretinal membrane formation. Given the range of ocular manifestations of HIV, routine ocular examinations and screening for visual loss are recommended in patients with CD4 counts <50 cells/μL. With the increasing longevity of these patients due to the use of HAART, treatment of IRU may become an issue in the future. The aim of this paper is to review the current literature concerning immune recovery uveitis. The definition, epidemiology, pathophysiology, clinical findings, complications, diagnosis, and treatment are presented.
免疫重建葡萄膜炎(IRU)是接受高效抗逆转录病毒治疗(HAART)的艾滋病病毒(HIV)感染且患有巨细胞病毒性视网膜炎患者中最常见的免疫重建炎症综合征形式。在HAART时代患有巨细胞病毒(CMV)的患者中,免疫恢复可能与更多的炎症并发症相关,包括黄斑水肿和视网膜前膜形成。鉴于HIV的眼部表现范围,建议CD4细胞计数<50个/μL的患者进行常规眼部检查和视力丧失筛查。随着使用HAART这些患者寿命的延长,IRU的治疗可能在未来成为一个问题。本文的目的是综述有关免疫恢复性葡萄膜炎的当前文献。介绍了其定义、流行病学、病理生理学、临床发现、并发症、诊断和治疗。