Pal P K., Lee C S., Samii A, Schulzer M, Stoessl A J., Mak E K., Wudel J, Dobko T, Tsui J K.C.
Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Purdy Pavilion, 2221 Westbrook Mall, British Columbia, V6T 2B5, Vancouver, Canada
Parkinsonism Relat Disord. 2001 Oct;7(4):305-309. doi: 10.1016/s1353-8020(00)00048-1.
We explored an objective method of measuring clinical severity of Parkinson's disease. Eighty-six patients with PD and 136 healthy subjects were studied. We serially carried out four types of finger tapping (FT) using a computerized drum machine: (i) repetitive one-finger tapping with an index-finger (F1K1); (ii) one-finger tapping on two keys separated by 20cm (F1K2); (iii) alternate tapping with index and middle fingers on two adjacent keys (F2K2); and (iv) F2K2 with contralateral activation (aF2K2). Analyses on FT included: (i) age and gender effects in healthy volunteers and Parkinson's disease; (ii) comparison between Parkinson patients and controls of similar age distribution; (iii) correlation with the Purdue Pegboard and Modified Columbia Scale in Disease; and (iv) in a subset of patients in whom PET scans were performed (n=30), correlation with 18F-DOPA uptake constant (Ki). In healthy subjects, there was a negative age effect on FT scores and a gender effect, with males scoring higher than females. All FT scores were significantly lower in the Parkinson patients, correlated with Purdue Peg Board, and inversely with the duration of illness, and with the Modified Columbia Scale. The 18F-DOPA Ki correlated significantly with aF2K2 (p=0.024), less so with PPB (p=0.038), but not with the Modified Columbia Scale. We conclude that alternating two-finger tapping with contralateral hand activation is a simple, objective test for measuring the severity of Parkinson's disease.
我们探索了一种测量帕金森病临床严重程度的客观方法。对86例帕金森病患者和136名健康受试者进行了研究。我们使用电脑鼓机连续进行了四种类型的手指敲击测试：（i）用食指进行重复性单指敲击（F1K1）；（ii）在相距20厘米的两个按键上进行单指敲击（F1K2）；（iii）食指和中指在两个相邻按键上交替敲击（F2K2）；以及（iv）对侧激活的F2K2（aF2K2）。对手指敲击测试的分析包括：（i）健康志愿者和帕金森病患者的年龄及性别影响；（ii）帕金森病患者与年龄分布相似的对照组之间的比较；（iii）与普渡钉板测试和疾病改良哥伦比亚量表的相关性；以及（iv）在进行了PET扫描的部分患者（n = 30）中，与18F - DOPA摄取常数（Ki）的相关性。在健康受试者中，手指敲击测试得分存在年龄负效应和性别效应，男性得分高于女性。帕金森病患者的所有手指敲击测试得分均显著较低，与普渡钉板测试相关，与病程呈负相关，且与疾病改良哥伦比亚量表相关。18F - DOPA Ki与aF2K2显著相关（p = 0.024），与普渡钉板测试相关性稍低（p = 0.038），但与疾病改良哥伦比亚量表无关。我们得出结论，对侧手激活的双指交替敲击是一种测量帕金森病严重程度的简单、客观的测试方法。
