Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany.
Private Practice for Neurosurgery, MVZ PAN Institute GmbH within the Department of Neurosurgery, Pan Klinik Am Neumarkt, Zeppelinstr 1 Neumarkt-Galerie, 50667, Cologne, Germany.
J Neural Transm (Vienna). 2020 Oct;127(10):1369-1376. doi: 10.1007/s00702-020-02246-3. Epub 2020 Aug 19.
Motor symptoms in patients with Parkinson's disease may be determined with instrumental tests and rating procedures. Their outcomes reflect the functioning and the impairment of the individual patient when patients are tested off and on dopamine substituting drugs. Objectives were to investigate whether the execution speed of a handwriting task, instrumentally assessed fine motor behavior, and rating scores improve after soluble levodopa application. 38 right-handed patients were taken off their regular drug therapy for at least 12 h before scoring, handwriting, and performance of instrumental devices before and 1 h after 100 mg levodopa intake. The outcomes of all performed procedures improved. The easy-to-perform handwriting task and the instrumental tests demand for fast and precise execution of movement sequences with considerable cognitive load in the domains' attention and concentration. These investigations may serve as additional tools for the testing of the dopaminergic response.
帕金森病患者的运动症状可以通过仪器测试和评分程序来确定。当患者停止和开始使用多巴胺替代药物进行测试时，他们的结果反映了个体患者的功能和障碍。目的是研究在手写任务的执行速度、仪器评估的精细运动行为以及评分方面，可溶性左旋多巴应用后是否会有所改善。在评分、手写和仪器设备的性能之前和之后，38 名右利手患者停止服用常规药物治疗至少 12 小时，然后在摄入 100 毫克左旋多巴后 1 小时进行。所有进行的程序的结果都有所改善。易于执行的手写任务和仪器测试需要快速、准确地执行具有相当认知负荷的运动序列，涉及注意力和集中力等领域。这些研究可以作为测试多巴胺反应的附加工具。
