β-酮脂酰酰基载体蛋白合酶III（FabH）对天蓝色链霉菌A3（2）的脂肪酸生物合成至关重要。
Beta-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2).
作者信息
Revill W P, Bibb M J, Scheu A K, Kieser H J, Hopwood D A
机构信息
John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom.
出版信息
J Bacteriol. 2001 Jun;183(11):3526-30. doi: 10.1128/JB.183.11.3526-3530.2001.
Abstract
The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.
摘要
天蓝色链霉菌的fab（脂肪酸生物合成）基因簇（fabD-fabH-acpP-fabF）共转录产生一种无 leader 的 mRNA 转录本。这些基因之一，fabH，编码一种 III 型酮酰基合酶，它对天蓝色链霉菌脂肪酸生物合成的起始至关重要，并被认为对此负责。
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2
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Microbiology (Reading). 1999 Sep;145 ( Pt 9):2221-2227. doi: 10.1099/00221287-145-9-2221.
3
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4
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FEMS Microbiol Lett. 1997 Oct 15;155(2):223-9. doi: 10.1111/j.1574-6968.1997.tb13882.x.
5
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J Bacteriol. 1996 Oct;178(19):5660-7. doi: 10.1128/jb.178.19.5660-5667.1996.
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7
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