A fluid connection: cholesterol and Abeta.
作者信息
Wolozin B
机构信息
Department of Pharmacology, Molecular Pharmacology Laboratory, Loyola University Medical Center, 2160 South First Street, Building 102, Room 3634, Maywood, IL 60153, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5371-3. doi: 10.1073/pnas.101123198.
Abstract
摘要
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本文引用的文献
1
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.低胆固醇通过其对α-分泌酶ADAM 10的作用刺激非淀粉样蛋白生成途径。
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20. doi: 10.1073/pnas.081612998. Epub 2001 Apr 17.
2
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.辛伐他汀在体外和体内均能显著降低阿尔茨海默病β-淀粉样肽Aβ42和Aβ40的水平。
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5856-61. doi: 10.1073/pnas.081620098. Epub 2001 Apr 10.
3
How cells handle cholesterol.细胞如何处理胆固醇。
Science. 2000 Dec 1;290(5497):1721-6. doi: 10.1126/science.290.5497.1721.
4
Statins and the risk of dementia.他汀类药物与痴呆风险
Lancet. 2000 Nov 11;356(9242):1627-31. doi: 10.1016/s0140-6736(00)03155-x.
5
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.β-淀粉样前体蛋白与假定的β-分泌酶BACE及α-分泌酶ADAM10在小鼠和人类大脑中的协同表达
J Neurochem. 2000 Nov;75(5):2133-43. doi: 10.1046/j.1471-4159.2000.0752133.x.
6
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.与3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂相关的阿尔茨海默病患病率降低。
Arch Neurol. 2000 Oct;57(10):1439-43. doi: 10.1001/archneur.57.10.1439.
7
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.高胆固醇血症在转基因小鼠模型中加速阿尔茨海默病的淀粉样病理改变。
Neurobiol Dis. 2000 Aug;7(4):321-31. doi: 10.1006/nbdi.2000.0304.
8
Mechanisms of neurodegenerative disorders: Part 1: protein aggregates.神经退行性疾病的机制：第1部分：蛋白质聚集体
Arch Neurol. 2000 Jun;57(6):793-6. doi: 10.1001/archneur.57.6.793.
9
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.早老素1在去污剂溶解状态下与γ-分泌酶活性相关。
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. doi: 10.1073/pnas.110126897.
10
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.跨膜天冬氨酸蛋白酶BACE对阿尔茨海默病淀粉样前体蛋白的β-分泌酶切割。
Science. 1999 Oct 22;286(5440):735-41. doi: 10.1126/science.286.5440.735.
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