Hiroi H, Yasugi T, Matsumoto K, Fujii T, Watanabe T, Yoshikawa H, Taketani Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
J Surg Oncol. 2001 May;77(1):61-4. doi: 10.1002/jso.1067.
Because of a relative rarity of the cases with an artificial vagina, the incidence of a case with malignant disease arising in the neovagina is extremely rare. A case of adenocarcinoma arising from a neovagina is presented with a review of the literature.
A neovagina was constructed using the sigmoid colon at the age of 23 for congenital agenesis of the vagina, Rokitansky-Küster-Hauser syndrome. Subsequently, the patient had regular sexual intercourse for about 20 years. At the age of 53, she came to our outpatient clinic with a complaint of vaginal bleeding, and adenocarcinoma was found at the anterior wall of the neovagina adjoining the introitus. Total resection of the neovagina and adjuvant radiotherapy was performed. The pathological diagnosis was mucinous adenocarcinoma.
In view of relatively low incidence of mucinous carcinoma arising in the sigmoid colon along with the ectopic localization, this case may have implications for the understanding of pathogenesis of sigmoid colon cancer.
由于人工阴道病例相对罕见，新阴道发生恶性疾病的病例极为罕见。本文报告一例新阴道腺癌病例并复习相关文献。
患者23岁时因先天性阴道发育不全（罗基坦斯基-库斯特-豪泽综合征），采用乙状结肠构建新阴道。此后，患者有规律性生活约20年。53岁时，患者因阴道出血前来我院门诊就诊，在靠近阴道口的新阴道前壁发现腺癌。行新阴道全切除术及辅助放疗。病理诊断为黏液腺癌。
鉴于乙状结肠发生黏液癌的发生率相对较低以及异位定位，该病例可能有助于理解乙状结肠癌的发病机制。
