Williams D M, Lee G R, Cartwright G E
Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112, USA.
J Clin Invest. 1974 Feb;53(2):665-7. doi: 10.1172/JCI107603.
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.
超氧化物歧化酶对黄嘌呤氧化酶介导的铁蛋白、氯化铁或铁ADP中铁的还原具有显著的抑制作用。当超氧化物歧化酶浓度仅为正常猪肝中发现的浓度的约1%时,观察到最大抑制作用。这些观察结果表明,超氧阴离子自由基是黄嘌呤氧化酶在体外而非体内还原铁的中间产物。