人脑海绵状血管内皮细胞的再灌注损伤
Reoxygenation injury of human brain capillary endothelial cells.
作者信息
Nagashima T, Wu S, Yamaguchi M, Tamaki N
机构信息
Department of Neurosurgery Kobe University School of Medicine, Japan.
出版信息
Cell Mol Neurobiol. 1999 Feb;19(1):151-61. doi: 10.1023/a:1006980911551.
Abstract
- Many studies have demonstrated that endothelial cells from several species can generate oxygen free radicals when subjected to anoxia and reoxygenation. However, due to the heterogeneity of the endothelium within different organs and species, the effects of superoxide dismutase (SOD), catalase, and allopurinol on reoxygenated cultured cells remain quite controversial. 2. This review outlines the possible sources of oxygen free radicals within brain endothelial cells. 3. We examine the aspects of the effects of SOD catalase and allopurinol on cultured human brain capillary endothelial cells upon reoxygenation. 4. Also, we introduce briefly a method of culturing human brain capillary endothelial cells and present our experimental results on the effects of SOD, catalase, and allopurinol in these cultured cells following anoxia and reoxygenation.
摘要
- 许多研究表明，来自多个物种的内皮细胞在经历缺氧和复氧时会产生氧自由基。然而，由于不同器官和物种内内皮的异质性，超氧化物歧化酶（SOD）、过氧化氢酶和别嘌呤醇对复氧培养细胞的影响仍颇具争议。2. 本综述概述了脑内皮细胞内氧自由基的可能来源。3. 我们研究了SOD、过氧化氢酶和别嘌呤醇对复氧培养的人脑微血管内皮细胞的影响。4. 此外，我们简要介绍了一种培养人脑微血管内皮细胞的方法，并展示了我们关于SOD、过氧化氢酶和别嘌呤醇对这些培养细胞缺氧和复氧后影响的实验结果。
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