Soska V
Oddĕlení klinické biochemie FN U sv. Anny, Brno.
Vnitr Lek. 2000 Sep;46(9):506-9.
Elevated LDL-cholesterol levels and reduced HDL-cholesterol levels are independent risk factors for the development of ischaemic heart disease. Atherosclerosis is promoted also by some particles rich in triacylglycerols, in particular intermediate density lipoproteins (IDL), partly also very low density lipoproteins (VLDL). The risk of IHD is enhanced also by subfractions of LDLIII and protracted postprandial lipaemia, characterized by an increased concentration of remnants of chylomicrons. An independent risk factor is also an increased concentration of lipoprotein(a). When evaluating the cardiovascular risk of an actual patient it is always necessary to consider in addition to blood lipid levels also other non-lipid risk factors.
低密度脂蛋白胆固醇水平升高和高密度脂蛋白胆固醇水平降低是缺血性心脏病发生的独立危险因素。富含三酰甘油的某些颗粒，特别是中间密度脂蛋白（IDL），部分还有极低密度脂蛋白（VLDL），也会促进动脉粥样硬化。LDLIII亚组分和餐后长时间血脂异常（其特征为乳糜微粒残粒浓度增加）也会增加缺血性心脏病的风险。脂蛋白(a)浓度升高也是一个独立危险因素。在评估实际患者的心血管风险时，除了血脂水平外，总是还需要考虑其他非脂质危险因素。
