Hayes D W, Averett R K
Department of Podiatric Surgery and Traumatology, Broadlawns Medical Center, Des Moines, Iowa, USA.
Clin Podiatr Med Surg. 2001 Jan;18(1):161-76.
The ultimate goal of replacing cartilage with a bioengineered graft, autologous graft, or allograft is to replace the damaged articulating surface with tissue containing the anatomical, biomechanical, and functional properties of native articular cartilage, which will have resultant satisfactory clinical outcome. For transplanted articular cartilage to obtain the original histologic arrangement of hyaline cartilage with secure incorporation into host tissue, progressive integrated multidisciplinary research must continue. Although autologous chondrocyte transplantation of the talus is not yet FDA approved, this technique may provide the surgeons with a cutting-edge method to treat patients with nondegenerative osteochondral lesions of the talus and possibly other articulating joints of the foot.
用生物工程移植物、自体移植物或同种异体移植物替代软骨的最终目标是用具有天然关节软骨的解剖学、生物力学和功能特性的组织替代受损的关节表面，从而获得令人满意的临床结果。为了使移植的关节软骨获得透明软骨的原始组织学排列并牢固地融入宿主组织，必须继续进行逐步整合的多学科研究。虽然距骨自体软骨细胞移植尚未获得美国食品药品监督管理局（FDA）的批准，但该技术可能为外科医生提供一种前沿方法，用于治疗距骨非退行性骨软骨损伤以及可能的足部其他关节损伤的患者。
