Wang J H, Lu S N, Changchien C S, Lee C M, Tung H D, Chen T M
Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Republic of China.
J Ultrasound Med. 2001 May;20(5):539-44. doi: 10.7863/jum.2001.20.5.539.
To assess the therapeutic effect of percutaneous ethanol injection on small hepatocellular carcinoma by using a flash echo imaging system, a newly developed technique for detecting echoes from microbubble contrast agents more efficiently.
Six patients with 7 small nodular hepatocellular carcinomas, proved by fine-needle aspiration cytologic or pathologic examination, were included. Percutaneous ethanol injection was performed until there was no intratumoral color signal on conventional color and power Doppler ultrasonography. A bubble contrast agent was then injected, and flash echo imaging in the subtraction mode was performed for assessment of the therapeutic effect. Dynamic computed tomography, magnetic resonance imaging, and hepatic angiography were also used for evaluation of the therapeutic effect.
Five tumors had perfusion defects that were equal in size to or larger than the tumors. No tumor stain was shown on hepatic angiography. Two tumors had partial perfusion defects. Viable tumors were confirmed by tumor resection in 1 case and cytologic examination in the other.
Our preliminary results show that flash echo imaging with subtraction has potential value in evaluation of the therapeutic effect of percutaneous ethanol injection on small hepatocellular carcinoma.
通过使用一种新开发的能更高效检测微泡造影剂回声的快速超声成像系统，评估经皮乙醇注射治疗小肝细胞癌的疗效。
纳入6例经细针穿刺细胞学或病理检查证实患有7个小的结节性肝细胞癌的患者。进行经皮乙醇注射，直至在传统彩色和能量多普勒超声检查中肿瘤内无彩色信号。然后注射一种气泡造影剂，并采用相减模式进行快速超声成像以评估治疗效果。动态计算机断层扫描、磁共振成像和肝血管造影也用于评估治疗效果。
5个肿瘤出现了与肿瘤大小相等或更大的灌注缺损。肝血管造影未显示肿瘤染色。2个肿瘤有部分灌注缺损。1例通过肿瘤切除、另1例通过细胞学检查证实存在存活肿瘤。
我们的初步结果表明，相减模式的快速超声成像在评估经皮乙醇注射治疗小肝细胞癌的疗效方面具有潜在价值。
