Badia L, Loughran S, Lund V
Institute of Laryngology and Otology, London, United Kingdom.
Am J Rhinol. 2001 Mar-Apr;15(2):117-9. doi: 10.2500/105065801781543736.
The objective of this paper is to determine whether there is a relationship among obesity, gender, and the risk of development of primary spontaneous cerebrospinal fluid (CSF) rhinorrhea. A retrospective case review of all the patients with CSF rhinorrhea treated at our unit over a 10-year period is presented. From a series of 20 patients, we studied 9 cases of primary spontaneous CSF rhinorrhea; 6 patients were female (mean age 50 +/- 10 years) and 3 male (mean age 61 +/- 7 years). All the female patients were clinically obese, i.e., they had a body mass index >30 kg/m2. All the male patients had a body mass index within normal parameters. We review the postulated etiologic factors of this uncommon condition and study the pathophysiologic basis for obese patients to have CSF rhinorrhea. This study suggests a relationship between obese females and the risk of developing a primary spontaneous CSF rhinorrhea.
本文的目的是确定肥胖、性别与原发性自发性脑脊液鼻漏发生风险之间是否存在关联。本文呈现了对我院10年间收治的所有脑脊液鼻漏患者进行的回顾性病例分析。在20例患者中，我们研究了9例原发性自发性脑脊液鼻漏患者；其中6例为女性（平均年龄50±10岁），3例为男性（平均年龄61±7岁）。所有女性患者临床上均肥胖，即她们的体重指数>30kg/m²。所有男性患者的体重指数均在正常范围内。我们回顾了这种罕见疾病的假定病因，并研究肥胖患者发生脑脊液鼻漏的病理生理基础。本研究表明肥胖女性与原发性自发性脑脊液鼻漏发生风险之间存在关联。
