Leonard W J
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA.
Int J Hematol. 2001 Apr;73(3):271-7. doi: 10.1007/BF02981951.
The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after activation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.
Janus家族酪氨酸激酶-信号转导子和转录激活子（Jak-STAT）信号通路被干扰素和I型细胞因子广泛利用。这些细胞因子和干扰素激活Janus家族酪氨酸激酶（Jak激酶），后者进而磷酸化并激活STAT蛋白。在激活之前，STAT蛋白是胞质蛋白；然而，激活后它们会转运至细胞核，在细胞核中作为转录因子发挥作用。本综述总结了Jak-STAT通路的显著特征，并重点关注不同Jak激酶和STATs在体内的功能作用。
