Pepple D J, Hardeman M R, Mullings A M, Reid H L
Department of Basic Medical Sciences, University of the West Indies, Kingston, Jamaica.
Clin Hemorheol Microcirc. 2001;24(1):43-8.
One of the features of preeclampsia is impaired blood rheology due to altered erythrocyte aggregation and erythrocyte deformability. We investigated these two parameters which affect the viscosity of blood, along with serum and intraerythrocytic magnesium concentrations, immunoglobulin titres and fibrinogen concentration in 12 preeclamptic women. Eighteen (18) other non-preeclamptic, gestation-matched women acted as controls. Erythrocyte deformability, expressed as elongation index (EI), and erythrocyte aggregation expressed as aggregation half-time (t 1/2) were measured with the Laser-assisted Optical Rotational Cell Analyser (LORCA). Serum and intraerythrocytic magnesium concentrations were analysed by atomic absorption spectrometry, immunoglobulin titres by radial immunodiffusion and fibrinogen concentration by a clot weight technique. There was no statistically significant difference in these parameters between preeclamptics and controls suggesting that erythrocyte deformability and aggregation as well as serum and intraerythrocytic concentrations, fibrinogen levels and immunoglobulin titres are not altered in preeclampsia. Further investigations are required in severe preeclampsia and in preeclamptic women taking magnesium sulphate supplement.
先兆子痫的特征之一是由于红细胞聚集和红细胞变形性改变导致血液流变学受损。我们研究了影响血液粘度的这两个参数，以及12例先兆子痫妇女的血清和红细胞内镁浓度、免疫球蛋白滴度和纤维蛋白原浓度。另外18例妊娠匹配的非先兆子痫妇女作为对照。用激光辅助光学旋转细胞分析仪（LORCA）测量以伸长指数（EI）表示的红细胞变形性和以聚集半衰期（t 1/2）表示的红细胞聚集。血清和红细胞内镁浓度采用原子吸收光谱法分析，免疫球蛋白滴度采用放射免疫扩散法分析，纤维蛋白原浓度采用凝块重量技术分析。先兆子痫患者和对照组之间这些参数无统计学显著差异，提示先兆子痫患者的红细胞变形性和聚集以及血清和红细胞内浓度、纤维蛋白原水平和免疫球蛋白滴度未改变。对于重度先兆子痫患者和服用硫酸镁补充剂的先兆子痫妇女，需要进一步研究。
