ETS家族转录因子在血管发育和血管生成中的作用。
Role of ETS family transcription factors in vascular development and angiogenesis.
作者信息
Sato Y
机构信息
Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
出版信息
Cell Struct Funct. 2001 Feb;26(1):19-24. doi: 10.1247/csf.26.19.
The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.
ETS转录因子家族由一个保守的DNA结合ETS结构域定义，该结构域形成一个有翼的螺旋-转角-螺旋结构基序。这个转录因子家族参与了多种生物学功能，包括细胞生长和分化以及器官发育。在这个家族的成员中，ETS-1、ERG、Fli-1、TEL和NERF-2在内皮细胞及其祖细胞中表达。本综述将总结ETS家族转录因子在血管发育和血管生成中的作用。
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