[先天性凝血缺陷患者的口腔治疗方法]
[Stomatologic approach in patients with congenital coagulation deficit].
作者信息
Battista F, Dell'Aquila A, Ferrigno M, Vitiello G
机构信息
ASL Napoli 1, Servizio di Odontostomatologia e Chirurgia Maxillo-Facciale, Presidio Ospedaliero S. Giovanni Bosco, Napoli.
出版信息
Minerva Stomatol. 2000 Nov-Dec;49(11-12):535-9.
BACKGROUND
The purpose of the present paper was to resolve postoperative bleeding after oral surgery in patients with congenital coagulative defects, avoid transfusion of clotting factors and improve the patient's quality of life.
METHODS
Since 1988, 1598 oral surgery procedures have been performed on patients with congenital coagulative defects treated with a protocol including pre- and postoperative tranexamic acid rinses.
RESULTS
The use of tranexamic acid mouth washing has obtained effective hemostasis in 86% of cases and only 4% of surgical procedures required clotting factor transfusions.
CONCLUSIONS
The results suggest that mouth washing with tranexamic acid prevents excessive oral bleeding in patients with congenital deficit of the coagulation system. Furthermore, a total elimination of the granulation tissue, that reduces the possibility of activation of the fibrinolytic mechanism, is also important.
背景
本文旨在解决先天性凝血缺陷患者口腔手术后的出血问题，避免输注凝血因子并提高患者生活质量。
方法
自1988年以来，已对接受包括术前和术后氨甲环酸冲洗方案治疗的先天性凝血缺陷患者进行了1598例口腔手术。
结果
使用氨甲环酸漱口在86%的病例中实现了有效止血，仅4%的手术需要输注凝血因子。
结论
结果表明，用氨甲环酸漱口可预防凝血系统先天性缺陷患者口腔过度出血。此外，彻底清除肉芽组织也很重要，这可降低纤维蛋白溶解机制激活的可能性。
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