蛇床子中香豆素类成分对兔阴茎海绵体的血管舒张作用。

Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.

作者信息

Chiou W F, Huang Y L, Chen C F, Chen C C

出版信息

Planta Med. 2001 Apr;67(3):282-4. doi: 10.1055/s-2001-12013.

DOI:10.1055/s-2001-12013

Abstract

Bioassay-directed fractionation led to the identification of four known coumarins, osthole (1), imperatorin (2), xanthotoxin (3), and isopimpinellin (4), from the ethanolic extract of the fruit of Cnidium monnieri (L.) Cusson. In phenylephrine (PE)-precontracted endothelium-intact rabbit corpus cavernosum, all four coumarins exhibited relaxing effect with the IC50 values for compounds 1, 2, 3, and 4 determined to be 2.14 +/- 0.73, 0.85 +/- 0.16, 1.24 +/- 0.45, and 18.4 +/- 8.10 microM, respectively. The four compounds were identified by comparison of their physical data (EIMS, 1H- and 13C-NMR) with those from published reports.

摘要

生物活性导向的分离法从蛇床子（Cnidium monnieri (L.) Cusson）果实的乙醇提取物中鉴定出了四种已知的香豆素，即蛇床子素（1）、欧前胡素（2）、花椒毒素（3）和异茴芹内酯（4）。在苯肾上腺素（PE）预收缩的完整内皮兔海绵体中，这四种香豆素均表现出舒张作用，化合物1、2、3和4的IC50值分别测定为2.14±0.73、0.85±0.16、1.24±0.45和18.4±8.10微摩尔。通过将它们的物理数据（电子轰击质谱、1H和13C核磁共振）与已发表报告中的数据进行比较，鉴定出了这四种化合物。