Faculty of Chemistry, Hanoi University of Education, 136 Xuan Thuy Road, Cau Giay, Hanoi, Vietnam.
Nat Prod Res. 2012;26(22):2107-11. doi: 10.1080/14786419.2011.619186. Epub 2011 Oct 21.
From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified. Their structures were elucidated by spectroscopic analysis. Furthermore, 8-(3-hidroxy-3-methylbutyl)-7-methoxycoumarin (5) was synthesised from osthole (1) with a good yield (80%). In addition, compound 1 and its synthesis product (5) show moderate and non-selective cytotoxic activities against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).
从越南蛇床子的种子的乙酸乙酯提取物中，分离得到了三种香豆素：蛇床子素（1）、花椒毒素（2）、欧前胡素（3）和一种甾体化合物，豆甾醇（4）。通过光谱分析阐明了它们的结构。此外，还从蛇床子素（1）合成了 8-(3-羟基-3-甲基丁基)-7-甲氧基香豆素（5），收率良好（80%）。此外，化合物 1 及其合成产物（5）对四种癌细胞 KB（人表皮癌细胞）、MCF7（人乳腺癌细胞）、SK-LU-1（人肺癌细胞）和 HepG2（肝癌细胞）表现出中等非选择性细胞毒性活性。
